Quantitative Biomarkers

Precision. Accuracy.

inVentiv Health Clinical laboratories provide mass spectrometry-based and immunochemical analyses for the development, validation, and measurement of biomarkers, including targeted and non-targeted biochemical and protein profiling. Our methods assure precise, accurate measurement of biomarkers for therapeutic disease endpoints for infectious and autoimmune diseases, cardiovascular risk, and blood components including hormones, cytokines, chemokines, and acute-phase reactants.

Analytes Method Calibration Range Regulatory Compliance Disease Mechanism Related Pathologies  
1-Alpha,25 Dihydroxyvitamin D2 LC/MS/MS 2-50 pg/ ml GLP Health Supplementary Nutritional Status Dihydroxyvitamin D
2,3-Dinor-6-Keto PGF1Alpha; 11-Dehydro-Thromboxane B2; Tetranor-PGEM GC/MS/MS 20-500pg/mL; 40-2000pg/mL; 200-10,000pg/mL GLP Prostaglandins Cardiovascular, Oncology, Pain , Dinor Keto PGF Alpha; Dehydro Thromboxane B ; Tetranor PGEM
ACTH IRMA GCP Steroid Pituitary, Cytokines, CRF ACTH
Albumin Colorimetric 35-48 g/L GCP General Malnutrition, Liver, Renal, Stress Albumin
C-Peptide RIA 0.3-2.4 mmol/L GCP Diabetes Diabetes (1,2), Liver, Insulinoma C Peptide
C-Peptide RIA/Chemiluminescence GCP Diabetes Diabetes (1,2), Liver, Insulinoma C Peptide
Calcium Colorimetic 2.5-8.0 mmol/L GCP Bone Osteoperosis, Heart, Diabetes Calcium
Cholecalciferol LC/MS/MS 0.5-50 ng/mL GLP Health Supplementary Nutritional Status Cholecalciferol
Cholesterol Enzymatic 3.20-4.60 mmol/L GCP Lipid Gallbladder, Metabolic, Heart Cholesterol
Cortisol LC/MS/MS/Chemiluminescence 0.2-50 ng/mL GLP/GCP Steroid Addison, Cushing, Aids, Crohn's Cortisol
DHEA RIA 1.8-10.3 umol/L GCP/GLP Steroid Alzheimer's, Metabolic Syndrome DHEA
Eicosapentaenoic Acid (EPA); Docosahexaenoic Acid (DHA) LC/MS/MS 2-200 µg/mL; 10-1000 µg/mL GLP Health Supplementary Nutritional Status Eicosapentaenoic Acid (EPA); Docosahexaenoic Acid (DHA)
Estradiol RIA / MEIA <44-146 pmol/L GCP Steroid Pituitary, Skin, Thrombolic, Heart Estradiol
Estradiol; Estrone LC/MS/MS 5-1000 pg/mL; 2.5-500 pg/mL GLP Steroid Pituitary, Skin, Thrombolic, Heart Estradiol; Estrone
Estradiol; Estrone; Estrone Conjugates; Testosterone; Androstenedione GC/MS/MS 0.625-80pg/mL; 1.56-200pg/mL; 3.13-800pg/mL; 25-3200pg/mL; 25-3200pg/mL GLP Steroid Oncology, Cardiovascular, Alzheimer's, Hormone Replacement Therapy Estradiol; Estrone; Estrone Conjugates; Testosterone; Androstenedione
Estrone (Total) LC/MS/MS 25-25000 pg/mL GLP Steroid Acne, Adrenal, Age-associated Estrone (Total)
Fibrinogen Turbidometric 2.0-4.0 g/L GCP Coagulation Alzheimer's. CHD, Gum, Blood Fibrinogen
FSH RIA/MEIA 2-100 mIU/mL GCP/GLP Pituitary Autoimmune, cancer, Addson's FSH
Glucose Colorimetic/Elisa 12-300 mg/dL GCP/GLP Diabetes Diabetes, CHD, Kidney, Glycogen Glucose
Growth Hormone, Human (hGH) RIA 1-40 ng/mL GCP Growth Modulation Acromegaly, Cruetzfeldt-Jakob Growth Hormone, Human (hGH)
Growth Hormone, Human (hGH) ELISA 0.1-15 ng/mL GCP Growth Modulation Acromegaly, Cruetzfeldt-Jakob Growth Hormone, Human (hGH)
Hemoglobin Spectroscopy 120-160 g/L GCP General Congenital HD, S.Cell and others Hemoglobin
IGF RIA/EIA 116-358 ng/mL GCP Growth Modulation Alzheimer's, Dwarfism, Infertility IGF
IGF ELISA 9-600 ng/mL GCP Growth Modulation Alzheimer's, Dwarfism, Infertility IGF
Insulin RIA 5-63 pmol/L GCP Diabetes Insulin Resistance; CHD, Obesity Insulin
L-Citrulline LC/MS/MS 150-10,000ng/mL GLP Amino Acid Rheumatoid arthritis L Citrulline
Leukotriene B4 LC/MS/MS 25-12500 pg/mL GLP Miscellaneous Inflammation Leukotriene B
LH RIA/LEIA 3-200 mIU/mL GCP/GLP Pituitary Autoimmune, Parkinson, Raynaud's LH
Niacin LC/MS/MS 25-10000 ng/mL GLP Vitamin Raynaud, Alzheimer's Dementia Niacin
Nicotinuric Acid LC/MS/MS 2-800 ng/mL GLP Health Supplementary Nutritional Status Nicotinuric Acid
Phosphorus Colorimetic 0.87-1.45 mmol/L GCP Bone Acidosis, Metabolism, CKD Phosphorus
Potassium ICP/ISE 3.4-5.0 mmol/L GCP Cardio/Hypertension IBD, CKD, Acidosis, Sick-Sinus Potassium
Progesterone LC/MS/MS 20-20000 pg/mL GLP/GCP Cardio/Hypertension Hypothalamic, Breast Cancer, HD Progesterone
Prothrombin EIA 11.8-15.1 sec GCP Coagullation Hemophilia, Hypoprothrombinemia Prothrombin
SHBG RIA/EIA MALE: 10-55 nmol/L, FEMALE: 18-114 nmol/L GCP Steroid Alzheimer's Cancer, Age-related SHBG
Sodium ISE 135-145 mmol/L GCP Cardio/Hypertension Blood pressure, Stroke, Kidney Sodium
T3 (Total) RIA 0.25-10 ng/mL GLP Thyroid Autoimmune, Thyroid Disease T (Total)
T3; T4 LC/MS/MS 2.5-1000 ng/mL; 0.25-100 ng/mL GLP Thyroid Autoimmune, Thyroid Disease T ; T
Testosterone GC/MS/MS MALE: 8.4-28.7 nmol/L, FEMALE: 0.5-2.6 nmol/L GLP Steroid Sexual Dysfunction, Age, Cancer Testosterone
Testosterone LC/MS/MS/Chemiluminescence 60-12000 pg/mL GLP/GCP Steroid Sexual Dysfunction, Age, Cancer Testosterone
Thromboxane B2 LC/MS/MS 10 -10000 pg/mL GLP Endocrinology Platelet Activation; Inflammation Thromboxane B
TSH RIA/Chemiluminescence 0.47-4.64 uUI/mL GCP Steroid Thyroid disease, Autoimmune, Age TSH